Germ Cell Transplantation and Testis Tissue Xenografting in Mice
نویسندگان
چکیده
منابع مشابه
Xenografting of human fetal testis tissue: a new approach to study fetal testis development and germ cell differentiation
BACKGROUND Abnormal fetal testis development can result in disorders of sex development (DSDs) and predispose to later testicular dysgenesis syndrome (TDS) disorders such as testicular germ cell tumours. Studies of human fetal testis development are hampered by the lack of appropriate model, and intervention systems. We hypothesized that human fetal testis xenografts can recapitulate normal dev...
متن کاملRecent developments in testis tissue xenografting.
Development of the mammalian testis and spermatogenesis involve complex processes of cell migration, proliferation, differentiation, and cell-cell interactions. Although our knowledge of these processes has increased in the last few decades, many aspects still remain unclear. The lack of suitable systems that allow to recapitulate and manipulate both testis development and spermatogenesis ex si...
متن کاملXenografting of adult mammalian testis tissue.
Xenografting of testis tissue from immature males from several mammalian species to immunodeficient mouse hosts results in production of fertilization-competent sperm. However, the efficiency of testis tissue xenografting from adult donors has not been critically evaluated. Testis tissue xenografting from sexually mature animals could provide an option to preserve the genetic material from valu...
متن کاملPromise and limitations of germ cell transplantation in the testis.
In 1994, the first successful stem cell transplantation in the mammalian testis was reported (Brinster and Zimmermann, 1994). In the early studies, a mixture of germ cells from either mouse or rat testes was successfully transplanted by microinjection into a germ cell-depleted recipient mouse testis (Clouthier et al, 1996). Stem cells in this mixture colonized the repopulation of all of the ger...
متن کاملEthics of Tissue and Stem Cell Transplantation
Tissue and cell transplantation are regarded as a popular procedure in clinical sciences, prospecting a new horizon for several incurable diseases. Along with its usefulness, many ethical concerns accompany this development. The ethical issue of organ transplant is unique to the source used which includes: living related, living unrelated, cadaveric, and xenotransplant. Obtaining organs has a s...
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ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2012
ISSN: 1940-087X
DOI: 10.3791/3545